Which Senators pitcher, nicknamed "The Big Train," won 417 games?

Which pitcher threw a perfect game in 2010 and a no-hitter in the playoffs that same year? Which pitcher threw a perfect game at age 40 in 2004? Which Tigers pitcher lost a perfect game in 2010 because of a blown call on the final out? Which Mariners pitcher, "King Félix," threw a perfect game in 2012? The Cy Young Award is named after a pitcher whose real first name was what? Which Tigers slugger won the Triple Crown in 2012, the first since 1967? Which Red Sox player won the Triple Crown in 1967? Which Pirates star got exactly 3,000 career hits before his death?